The weeks shown in color represent the start and end points of chemical exposure for each study.
|Study Results||Study Details||References|
Results for PFAS (PFOS)Alterations in the expression in genes involved in secreted, cytoskeletal structure, extracellular matrix, ion channel and transporting, lipid metabolic, and transcription/ translation proteins.
Subjects: Sprague-Dawley rats
Chemical: PFAS (PFOS)
Low doses tested: 5.0 mg/kg bw/d
Other doses tested: 20.0 mg/kg bw/d
Route of administration: dissolved in Tween-20 and delivered through gavage
Exposure duration: gestational day 12 – gestational day 18 (comparable to human prenatal development from approximately day 1 of week 4 to day 1 of week 9)
Age of measurement: gestational day 18.5
|Reference [PubMed Link]
Ye L, Zhao B, Yuan K, Chu Y, Li C, Zhao C, Lian QQ, Ge RS. 2012. Gene expression profiling in fetal rat lung during gestational perfluorooctane sulfonate exposure. Toxicol Lett 209(3):270-276.